Chemical Synthesis Against Human Diseases
Chemoselective reactions with mutant residues offers a precise way to target the diseased cells without harming the healthy ones.
New Covalent Chemistry to Target Disease Mutations
We draw inspiration from natural products and develop new chemistry to form covalent bonds with biomolecules.
Modulation of Antigen Presentation
We use chemistry to perturb the key processes that educate our immune cells to detect viruses and cancer.
In cancer, activating T cells could help them kill the malignant cells, while in autoimmune diseases, suppressing T cells could prevent tissue damage.
Chemical Control of T Cell Function
We use small molecules to activate or deactivate T cells.