Graduate and Postdoctoral

Zhang, Z.; Fan, Q.; Luo, X.; Lou, K.; Weiss, W. A.; Shokat, K. M. Brain-Specific mTOR Inhibition with Binary Pharmacology. Nature 2022, Ahead of print. PMID: 36104566.

Zhang, Z.*; Rohweder, P.J.*; Ongpipattanakul, C.; Basu, K.; Bohn, M.; Steri, V.; Dugan, E.; Hann, B.; Shokat, K. M.; Craik, C. Covalent K-Ras(G12C) ligand induces MHC-I presentation of haptenated peptide neoepitopes targetable by immunotherapy. Cancer Cell 2022, 40, 1060-1069. PMID: 36089883.

Zhang, Z.*; Morstein, J.*; Ecker, A.E*.; Guiley, K.Z.; Shokat, K.M. Chemoselective Covalent Modification of K-Ras(G12R) with a Small Molecule Electrophile. J. Am. Chem. Soc. 2022, 144, 15916-15921. PMID: 36001446.

Zhang, Z.; Guiley, K.Z.; Shokat, K.M. Chemical acylation of an acquired serine suppresses oncogenic signaling of K-Ras(G12S). Nature Chem. Bio. 2022, Ahead of print. PMID: 35864332.

Yang, G.; Francis, D.; Krycer, J.R.; Larance, M.; Zhang, Z.; Novotny, C.J.; Diaz-Vegas, A.; Shokat, K.M.; James, D.E. Dissecting the biology of mTORC1 beyond rapamycin. Sci. Signal. 2022, 14, eabe0161. PMID: 34546793.

Tummino, T. A.; Rezelj, V. V.; Fischer, B.; Fischer A.; O’Meara, M. J.; Monel, B.; Vallet, T.; Zhang, Z.; Alon, A.; O’Donnell, H. R.; Lyu, J.; Schadt, H.; White, K. M.; Krogen, N. J.; Urban, L.; Shokat, K.; Kruse, A.; Garcia-Sastre A.; Schwartz, O.; Moretti, F.; Vignuzzi, M.; Pognan, F.; Shoichet, B. K. Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2. Science 2021, 373, 541-547. PMID: 34326236.

Ehinger, Y.*; Zhang, Z.*; Phamluoong, K.; Soneja D.; Shokat, K. M.; Ron, D. Brain-Specific Inhibition of mTORC1 by a Dual Drug Strategy: A Novel Approach for the Treatment of Alcohol Use Disorder. Nature Communications 2021, 12, 4407. PMID: 34315870.

Zhang, Z.; Gao, R.; Hu, Q; Peacock, H; Peacock, D. M.; Shokat, K. M.; Suga, H. GTP State-Selective Cyclic Peptide Ligands of K-Ras(G12D) Block its Interaction with Raf. ACS Cent. Sci. 2020, 6(10), 1753–1761. PMID: 33145412.

Gordon, D. E.; Jang, G. M.; Bouhaddou, M.; Xu, J.; Obernier, K.; White, K. M.; O’Meara, M. J.; Rezelj, V. V.; Guo, J. Z.; Swaney, D. L.; Tummino, T. A.; Hüttenhain, R.; Kaake, R. M.; Richards, A. L.; Tutuncuoglu, B.; Foussard, H.; Batra, J.; Haas, K.; Modak, M.; Kim, M.; Haas, P.; Polacco, B. J.; Braberg, H.; Fabius, J. M.; Eckhardt, M.; Soucheray, M.; Bennett, M. J.; Cakir, M.; McGregor, M. J.; Li, Q.; Meyer, B.; Roesch, F.; Vallet, T.; Mac Kain, A.; Miorin, L.; Moreno, E.; Naing, Z. Z. C.; Zhou, Y.; Peng, S.; Shi, Y.; Zhang, Z.; Shen, W.; Kirby, I. T.; Melnyk, J. E.; Chorba, J. S.; Lou, K.; Dai, S. A.; Barrio-Hernandez, I.; Memon, D.; Hernandez-Armenta, C.; Lyu, J.; Mathy, C. J. P.; Perica, T.; Pilla, K. B.; Ganesan, S. J.; Saltzberg, D. J.; Rakesh, R.; Liu, X.; Rosenthal, S. B.; Calviello, L.; Venkataramanan, S.; Liboy-Lugo, J.; Lin, Y.; Huang, X. P.; Liu, Y. F.; Wankowicz, S. A.; Bohn, M.; Safari, M.; Ugur, F. S.; Koh, C.; Savar, N. S.; Tran, Q. D.; Shengjuler, D.; Fletcher, S. J.; O’Neal, M. C.; Cai, Y.; Chang, J. C. J.; Broadhurst, D. J.; Klippsten, S.; Sharp, P. P.; Wenzell, N. A.; Kuzuoglu-Ozturk, D.; Wang, H. Y.; Trenker, R.; Young, J. M.; Cavero, D. A.; Hiatt, J.; Roth, T. L.; Rathore, U.; Subramanian, A.; Noack, J.; Hubert, M.; Stroud, R. M.; Frankel, A. D.; Rosenberg, O. S.; Verba, K. A.; Agard, D. A.; Ott, M.; Emerman, M.; Jura, N.; von Zastrow, M.; Verdin, E.; Ashworth, A.; Schwartz, O.; d’Enfert, C.; Mukherjee, S.; Jacobson, M.; Malik, H. S.; Fujimori, D. G.; Ideker, T.; Craik, C. S.; Floor, S. N.; Fraser, J. S.; Gross, J. D.; Sali, A.; Roth, B. L.; Ruggero, D.; Taunton, J.; Kortemme, T.; Beltrao, P.; Vignuzzi, M.; García-Sastre, A.; Shokat, K. M.; Shoichet, B. K.; Krogan, N. J. A SARS-CoV-2 Protein Interaction Map Reveals Targets for Drug Repurposing. Nature 2020, 583, 459–468. PMID: 32353859.

Zhang, Z.; Shokat, K. M.; Bifunctional Small Molecule Ligands of K-Ras Induce Its Association with Immunophilin Proteins. Angew. Chem. Int. Ed. 2019, 58, 16314–16319. PMID: 31557383.

Katsuno, Y.; Meyer, D. S.; Zhang, Z.; Shokat, K. M.; Akhurst, R. J.; Miyazono, K.; Derynck, R. Chronic TGF-β exposure drives stabilized EMT, tumor stemness and cancer drug resistance with vulnerability to bitopic mTOR inhibition. Sci. Signal. 2019, 12, eaau8544. PMID: 30808819.

Mortison J. D.; Schenone M.; Myers, J. A.; Zhang, Z.; Chen, L.; Ciarlo, C.; Comer, E.; Natchiar, S. K.; Carr, S. A.; Klaholz, B. P.; Myers, A. G. Tetracyclines Modify Translation by Targeting Key Human rRNA Substructures. Cell Chem. Bio. 2018, 25, 1506–1518. PMID: 30318467.

Seiple, I. B.*; Zhang, Z.*; Jakubec, P.; Langlois, A.; Wright, P. M.; Hog, D. T.; Yabu, K.; Allu, S. R.; Fukuzaki, T.; Carlsen, P. N.; Kitamura, Y.; Zhou, X.; Condakes, M. L.; Szczypiński, F. T.; Green, W. D.; Myers, A. G. A Platform for the Discovery of New Macrolide Antibiotics. Nature 2016, 533, 338–345. PMID: 27193679.

Zhang, Z.; Fukuzaki, T.; Myers, A. G. A Concise, Practical Synthesis of D-Desosamine and Analogs Employing a Novel Strategy for the Rapid Assembly of 3-Amino Sugars. Angew. Chem. Int. Ed. 2016, 55, 523-527. PMID: 26612347.

Zhang, Z.; Kitamura, Y.; Myers, A. G. An Efficient Directed Claisen Reaction Allows for Rapid Construction of 5,6-Disubstituted 1,3-Dioxin-4-ones. Synthesis 2015, 47, 2709-2712.

Seiple, I. B.; Mercer, J. A. M.; Sussman, R. J.; Zhang, Z. Stereocontrolled Synthesis of Syn-β-Hydroxy-α-Amino Acids by Direct Aldolization of Pseudoephenamine Glycinamide. Angew. Chem. Int. Ed. 2014, 33, 4642-4646. PMID: 24692320.

Ren, W.; Chen, Z.; Xiao, Q.; Li, Y.; Sun, T; Zhang, Z; Ye, Q; Feng, F; You, L; Zhao, M.; Xu, L; Tang, Y; Chen, J.; Yang, Z. Diastereoselective Total Synthesis of (±)-Schindilactone A, Part 3: The Final Phase and Completion. Chem. Asian. J. 2012, 7, 2341-2350. PMID: 22761030.

Ren, W.; Bian, Y.; Zhang, Z.; Shang, H.; Zhang, P.; Chen, Y.; Yang, Z.; Luo, T.; Tang, Y. Enantioselective and Collective Syntheses of Xanthanolides Involving a Controllable Dyotropic Rearrangement of cis-β-Lactones. Angew. Chem. Int. Ed. 2012, 124, 7090-7094. PMID: 22674838.

Zhang, Z.; Chen, J.; Yang, Z.; Tang, Y. A Rapid Biomimetic Total Synthesis of (±)-Rossinone B. Org. Lett. 2010, 12, 5554-5557. PMID: 21062011.